Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE(2) biosynthesis by sonlicromanol’s metabolite KH176m

Increased prostaglandin E2 (PGE(2)) levels were detected in mitochondrial disease patient cells harboring nuclear gene mutations in structural subunits of complex I, using a metabolomics screening approach. The increased levels of this principal inflammation mediator normalized following exposure of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jiang, X., Renkema, H., Pennings, B., Pecheritsyna, S., Schoeman, J. C., Hankemeier, T., Smeitink, J., Beyrath, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806836/
https://ncbi.nlm.nih.gov/pubmed/33441600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79466-w
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