Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice

Mutations in BRCA genes are the leading cause of hereditary breast cancer. Current options to prevent cancer in these high-risk patients, such as anti-estrogen drugs and radical mastectomy, are limited by lack of efficacy, undesirable toxicities, or physical and emotional challenges. We have previou...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Zhang, Di, Singh, Bijay, Moerland, Jessica, Mitchell, Owen, Lockwood, Lizbeth, Carapellucci, Sarah, Sridhar, Srinivas, Liby, Karen T.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806744/
https://ncbi.nlm.nih.gov/pubmed/33441637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79663-7
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