Sustained Release Talazoparib Implants for Localized Treatment of BRCA1-deficient Breast Cancer

Talazoparib, a potent PARP inhibitor, has shown promising clinical and pre-clinical activity by inducing synthetic lethality in cancers with germline Brca1/2 mutations. Conventional oral delivery of Talazoparib is associated with significant off-target effects, therefore we sought to develop new del...

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Библиографические подробности
Опубликовано в: :Theranostics
Главные авторы: Belz, Jodi E., Kumar, Rajiv, Baldwin, Paige, Ojo, Noelle Castilla, Leal, Ana S., Royce, Darlene B., Zhang, Di, van de Ven, Anne L., Liby, Karen T., Sridhar, Srinivas
Формат: Artigo
Язык:Inglês
Опубликовано: Ivyspring International Publisher 2017
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695017/
https://ncbi.nlm.nih.gov/pubmed/29158830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.18563
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