Dissecting the contribution of O-Antigen and proteins to the immunogenicity of Shigella sonnei generalized modules for membrane antigens (GMMA)

GMMA are exosomes released from engineered Gram-negative bacteria resembling the composition of outer membranes. We applied the GMMA technology for the development of an O-Antigen (OAg) based vaccine against Shigella sonnei, the most epidemiologically relevant cause of shigellosis. S. sonnei OAg has...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mancini, Francesca, Gasperini, Gianmarco, Rossi, Omar, Aruta, Maria Grazia, Raso, Maria Michelina, Alfini, Renzo, Biagini, Massimiliano, Necchi, Francesca, Micoli, Francesca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806729/
https://ncbi.nlm.nih.gov/pubmed/33441861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80421-y
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