Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion

We investigate whether suppressing the activation of the angiotensin II type 1a receptor (AT1a) can ameliorate severe chronic tubulointerstitial damage (TID) after renal ischemia reperfusion (IR) using AT1a knockout homozygous (AT1a(−/−)) male mice. To induce severe chronic TID after renal IR, unila...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fujita, Yoko, Ichikawa, Daisuke, Sugaya, Takeshi, Ohata, Keiichi, Tanabe, Jun, Inoue, Kazuho, Hoshino, Seiko, Togo, Tatsuru, Watanabe, Minoru, Kimura, Kenjiro, Shibagaki, Yugo, Kamijo-Ikemori, Atsuko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806698/
https://ncbi.nlm.nih.gov/pubmed/33441837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80209-0
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