Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion

We investigate whether suppressing the activation of the angiotensin II type 1a receptor (AT1a) can ameliorate severe chronic tubulointerstitial damage (TID) after renal ischemia reperfusion (IR) using AT1a knockout homozygous (AT1a(−/−)) male mice. To induce severe chronic TID after renal IR, unila...

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Publicat a:Sci Rep
Autors principals: Fujita, Yoko, Ichikawa, Daisuke, Sugaya, Takeshi, Ohata, Keiichi, Tanabe, Jun, Inoue, Kazuho, Hoshino, Seiko, Togo, Tatsuru, Watanabe, Minoru, Kimura, Kenjiro, Shibagaki, Yugo, Kamijo-Ikemori, Atsuko
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806698/
https://ncbi.nlm.nih.gov/pubmed/33441837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80209-0
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