Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells

BACKGROUND: Previous studies showed that suppression of pyruvate carboxylase (PC) expression in highly invasive breast cancer cell line, MDA-MB-231 inhibits cell growth as a consequence of the impaired cellular biosynthesis. However, the precise cellular mechanism underlying this growth restriction...

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Veröffentlicht in:Biochem Biophys Rep
Hauptverfasser: Rattanapornsompong, Khanti, Khattiya, Janya, Phannasil, Phatchariya, Phaonakrop, Narumon, Roytrakul, Sittiruk, Jitrapakdee, Sarawut, Akekawatchai, Chareeporn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806519/
https://ncbi.nlm.nih.gov/pubmed/33490650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100903
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