CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3

Background: Metastasis is the major reason for the high mortality of colorectal cancer (CRC). However, the molecular mechanism underlying CRC metastasis remains unclear. Here, we report a novel role of homeobox B5 (HOXB5), a member of the HOX family, in promoting CRC metastasis. Method: The expressi...

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Veröffentlicht in:Theranostics
Hauptverfasser: Feng, Weibo, Huang, Wenjie, Chen, Jie, Qiao, Chenyang, Liu, Danfei, Ji, Xiaoyu, Xie, Meng, Zhang, Tongyue, Wang, Yijun, Sun, Mengyu, Tian, Dean, Fan, Daiming, Nie, Yongzhan, Wu, Kaichun, Xia, Limin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806482/
https://ncbi.nlm.nih.gov/pubmed/33456563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.52199
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