SIRT1 is downregulated by autophagy in senescence and aging

SIRT1 (Sir2) is an NAD(+)-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, immune response, and aging(1–5). While there is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the protein level is poorly unde...

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Publicat a:Nat Cell Biol
Autors principals: Xu, Caiyue, Wang, Lu, Fozouni, Parinaz, Evjen, Gry, Chandra, Vemika, Jiang, Jing, Lu, Congcong, Nicastri, Michael, Bretz, Corey, Winkler, Jeffrey D., Amaravadi, Ravi, Garcia, Benjamin A., Adams, Peter D., Ott, Melanie, Tong, Wei, Johansen, Terje, Dou, Zhixun, Berger, Shelley L.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805578/
https://ncbi.nlm.nih.gov/pubmed/32989246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00579-5
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