Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression

BACKGROUND: Endogenous retroviruses (ERVs) play a role in a variety of biological processes, including embryogenesis and cancer. DNA methyltransferase inhibitors (DNMTi)-induced ERV expression triggers interferon responses in ovarian cancer cells via the viral sensing machinery. Baseline expression...

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Publicado en:J Immunother Cancer
Autores principales: Natoli, Marina, Gallon, John, Lu, Haonan, Amgheib, Ala, Pinato, David J, Mauri, Francesco A, Marafioti, Teresa, Akarca, Ayse U, Ullmo, Ines, Ip, Jacey, Aboagye, Eric O, Brown, Robert, Karadimitris, Anastasios, Ghaem-Maghami, Sadaf
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2021
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805370/
https://ncbi.nlm.nih.gov/pubmed/33436485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001519
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