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Optimal biological dose: a systematic review in cancer phase I clinical trials
BACKGROUND: Classical phase 1 dose-finding designs based on a single toxicity endpoint to assess the maximum tolerated dose were initially developed in the context of cytotoxic drugs. With the emergence of molecular targeted agents and immunotherapies, the concept of optimal biological dose (OBD) wa...
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| Foilsithe in: | BMC Cancer |
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| Main Authors: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
BioMed Central
2021
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7805102/ https://ncbi.nlm.nih.gov/pubmed/33441097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-07782-z |
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