A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia

Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor (apelin-R) with LIT01-196, a metabolically stable apelin-17 analog, may be beneficial for treating the Syndrome of Inappropriate Antidiuresis, in which AVP...

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Published in:Nat Commun
Main Authors: Flahault, Adrien, Girault-Sotias, Pierre-Emmanuel, Keck, Mathilde, Alvear-Perez, Rodrigo, De Mota, Nadia, Estéoulle, Lucie, Ramanoudjame, Sridévi M., Iturrioz, Xavier, Bonnet, Dominique, Llorens-Cortes, Catherine
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804859/
https://ncbi.nlm.nih.gov/pubmed/33436646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20560-y
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