Disease-related cortical thinning in presymptomatic granulin mutation carriers

Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 nonca...

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Detalhes bibliográficos
Publicado no:Neuroimage Clin
Main Authors: Borrego-Écija, Sergi, Sala-Llonch, Roser, van Swieten, John, Borroni, Barbara, Moreno, Fermín, Masellis, Mario, Tartaglia, Carmela, Graff, Caroline, Galimberti, Daniela, Laforce, Robert, Rowe, James B, Finger, Elizabeth, Vandenberghe, Rik, Tagliavini, Fabrizio, de Mendonça, Alexandre, Santana, Isabel, Synofzik, Matthis, Ducharme, Simon, Levin, Johannes, Danek, Adrian, Gerhard, Alex, Otto, Markus, Butler, Chris, Frisoni, Giovanni, Sorbi, Sandro, Heller, Carolin, Bocchetta, Martina, Cash, David M, Convery, Rhian S, Moore, Katrina M, Rohrer, Jonathan D, Sanchez-Valle, Raquel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804836/
https://ncbi.nlm.nih.gov/pubmed/33418170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nicl.2020.102540
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