A Novel Therapeutic Approach to Corneal Alkaline Burn Model by Targeting Fidgetin-Like 2, a Microtubule Regulator

PURPOSE: The purpose of this study was to determine the efficacy of nanoparticle-encapsulated Fidgetin-like 2 (FL2) siRNA (FL2-NPsi), a novel therapeutic agent targeting the FL2 gene, for the treatment of corneal alkaline chemical injury. METHODS: Eighty 12-week-old, male Sprague-Dawley rats were di...

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Bibliografiske detaljer
Udgivet i:Transl Vis Sci Technol
Main Authors: Wang, Jessie, Dey, Abhinav, Kramer, Adam H., Miao, Yuan, Liu, Juan, Baker, Lisa, Friedman, Joel M., Nacharaju, Parimala, Chuck, Roy S., Zhang, Cheng, Sharp, David J.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804583/
https://ncbi.nlm.nih.gov/pubmed/33510956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.10.1.17
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