Triacylglycerol synthesis directed by glycerol-3-phosphate acyltransferases −3 and −4 is required for lipid droplet formation and the modulation of the inflammatory response during macrophage to foam cell transition.

BACKGROUND AND AIMS: The transition of macrophage to foam cells is a major hallmark of early stage atherosclerotic lesions. This process is characterized by the accumulation of large cytoplasmic lipid droplets containing large quantities of cholesterol esters (CE), triacylglycerol (TAG) and phosphol...

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Udgivet i:Atherosclerosis
Main Authors: Quiroga, Ivana Y., Pellon-Maison, Magali, Gonzalez, Marina C., Coleman, Rosalind A., Gonzalez-Baro, Maria R.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803380/
https://ncbi.nlm.nih.gov/pubmed/33260006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2020.11.022
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