Multiple Alu Exonization in 3′UTR of a Primate-Specific Isoform of CYP20A1 Creates a Potential miRNA Sponge

Alu repeats contribute to phylogenetic novelties in conserved regulatory networks in primates. Our study highlights how exonized Alus could nucleate large-scale mRNA–miRNA interactions. Using a functional genomics approach, we characterize a transcript isoform of an orphan gene, CYP20A1 (CYP20A1_Alu...

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Udgivet i:Genome Biol Evol
Main Authors: Bhattacharya, Aniket, Jha, Vineet, Singhal, Khushboo, Fatima, Mahar, Singh, Dayanidhi, Chaturvedi, Gaura, Dholakia, Dhwani, Kutum, Rintu, Pandey, Rajesh, Bakken, Trygve E, Seth, Pankaj, Pillai, Beena, Mukerji, Mitali
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802813/
https://ncbi.nlm.nih.gov/pubmed/33434274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evaa233
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