Hypoxia Increases β-Cell Death by Activating Pancreatic Stellate Cells within the Islet

BACKGROUND: Hypoxia can occur in pancreatic islets in type 2 diabetes mellitus. Pancreatic stellate cells (PSCs) are activated during hypoxia. Here we aimed to investigate whether PSCs within the islet are also activated in hypoxia, causing β-cell injury. METHODS: Islet and primary PSCs were isolate...

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Bibliographic Details
Published in:Diabetes Metab J
Main Authors: Kim, Jong Jin, Lee, Esder, Ryu, Gyeong Ryul, Ko, Seung-Hyun, Ahn, Yu-Bae, Song, Ki-Ho
Format: Artigo
Language:Inglês
Published: Korean Diabetes Association 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801750/
https://ncbi.nlm.nih.gov/pubmed/32431113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4093/dmj.2019.0181
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