Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer

Docosahexaenoic acid (DHA) is known to inhibit breast cancer in the rat. Here we investigated whether DHA itself or select metabolites can account for its antitumor action. We focused on metabolites derived from the lipoxygenase (LOX) pathway since we previously showed that they were superior anti-p...

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Pubblicato in:Sci Rep
Autori principali: Chen, Kun-Ming, Thompson, Henry, Vanden-Heuvel, John P., Sun, Yuan-Wan, Trushin, Neil, Aliaga, Cesar, Gowda, Krishne, Amin, Shantu, Stanley, Bruce, Manni, Andrea, El-Bayoumy, Karam
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801725/
https://ncbi.nlm.nih.gov/pubmed/33431978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79716-x
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