Reference standards for accurate validation and optimization of assays that determine integrated lentiviral vector copy number in transduced cells

Lentiviral vectors (LV) have emerged as a robust technology for therapeutic gene delivery into human cells as advanced medicinal products. As these products are increasingly commercialized, there are concomitant demands for their characterization to ensure safety, efficacy and consistency. Standards...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Paugh, Barbara S., Baranyi, Lajos, Roy, Andre, He, Hua-Jun, Harris, Lindsay, Cole, Kenneth D., Artlip, Moria, Raimund, Caroline, Langan, Patricia S., Jana, Srikanta, Orentas, Rimas J., Lin-Gibson, Sheng, Krueger, Winfried, Dropulić, Boro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801692/
https://ncbi.nlm.nih.gov/pubmed/33431989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79698-w
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