Reference standards for accurate validation and optimization of assays that determine integrated lentiviral vector copy number in transduced cells

Lentiviral vectors (LV) have emerged as a robust technology for therapeutic gene delivery into human cells as advanced medicinal products. As these products are increasingly commercialized, there are concomitant demands for their characterization to ensure safety, efficacy and consistency. Standards...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Sci Rep
المؤلفون الرئيسيون: Paugh, Barbara S., Baranyi, Lajos, Roy, Andre, He, Hua-Jun, Harris, Lindsay, Cole, Kenneth D., Artlip, Moria, Raimund, Caroline, Langan, Patricia S., Jana, Srikanta, Orentas, Rimas J., Lin-Gibson, Sheng, Krueger, Winfried, Dropulić, Boro
التنسيق: Artigo
اللغة:Inglês
منشور في: Nature Publishing Group UK 2021
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801692/
https://ncbi.nlm.nih.gov/pubmed/33431989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79698-w
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