Early impact of donor CYP3A5 genotype and Graft-to-Recipient Weight Ratio on tacrolimus pharmacokinetics in pediatric liver transplant patients

Tacrolimus (TAC) pharmacokinetics is influenced by the donor CYP3A5 genotype and the age of pediatric liver recipients. However, an optimization of a genotype-based algorithm for determining TAC starting is needed to earlier achieve stable target levels. As the graft itself is responsible for its me...

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Publicado en:Sci Rep
Main Authors: Pinon, Michele, De Nicolò, Amedeo, Pizzol, Antonio, Antonucci, Miriam, D’Avolio, Antonio, Serpe, Loredana, Dell’Olio, Dominic, Catalano, Silvia, Tandoi, Francesco, Romagnoli, Renato, Canaparo, Roberto, Calvo, Pier Luigi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801660/
https://ncbi.nlm.nih.gov/pubmed/33432012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79574-7
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