Early impact of donor CYP3A5 genotype and Graft-to-Recipient Weight Ratio on tacrolimus pharmacokinetics in pediatric liver transplant patients

Tacrolimus (TAC) pharmacokinetics is influenced by the donor CYP3A5 genotype and the age of pediatric liver recipients. However, an optimization of a genotype-based algorithm for determining TAC starting is needed to earlier achieve stable target levels. As the graft itself is responsible for its me...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Pinon, Michele, De Nicolò, Amedeo, Pizzol, Antonio, Antonucci, Miriam, D’Avolio, Antonio, Serpe, Loredana, Dell’Olio, Dominic, Catalano, Silvia, Tandoi, Francesco, Romagnoli, Renato, Canaparo, Roberto, Calvo, Pier Luigi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801660/
https://ncbi.nlm.nih.gov/pubmed/33432012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79574-7
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