Exemplar scoring identifies genetically separable phenotypes of lithium responsive bipolar disorder

Predicting lithium response (LiR) in bipolar disorder (BD) may inform treatment planning, but phenotypic heterogeneity complicates discovery of genomic markers. We hypothesized that patients with “exemplary phenotypes”—those whose clinical features are reliably associated with LiR and non-response (...

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Publicat a:Transl Psychiatry
Autors principals: Nunes, Abraham, Stone, William, Ardau, Raffaella, Berghöfer, Anne, Bocchetta, Alberto, Chillotti, Caterina, Deiana, Valeria, Degenhardt, Franziska, Forstner, Andreas J., Garnham, Julie S., Grof, Eva, Hajek, Tomas, Manchia, Mirko, Mattheisen, Manuel, McMahon, Francis, Müller-Oerlinghausen, Bruno, Nöthen, Markus M., Pinna, Marco, Pisanu, Claudia, O’Donovan, Claire, Rietschel, Marcella D. C., Rouleau, Guy, Schulze, Thomas, Severino, Giovanni, Slaney, Claire M., Squassina, Alessio, Suwalska, Aleksandra, Turecki, Gustavo, Uher, Rudolf, Zvolsky, Petr, Cervantes, Pablo, del Zompo, Maria, Grof, Paul, Rybakowski, Janusz, Tondo, Leonardo, Trappenberg, Thomas, Alda, Martin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801503/
https://ncbi.nlm.nih.gov/pubmed/33431852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-020-01148-y
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