High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance

High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance is largely unknown. Here, we show that lean mice become insulin resistant after being administered exosomes isolated from the feces of obese mice fed a HFD or from patients with type II diabetes. HFD alter...

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Udgivet i:Nat Commun
Main Authors: Kumar, Anil, Sundaram, Kumaran, Mu, Jingyao, Dryden, Gerald W., Sriwastva, Mukesh K., Lei, Chao, Zhang, Lifeng, Qiu, Xiaolan, Xu, Fangyi, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L., Bohler, Henry C. L., Wang, Baomei, Zhang, Shuangqin, Qin, Chao, Xu, Ziying, Han, Xianlin, McClain, Craig J., Teng, Yun, Zhang, Huang-Ge
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801461/
https://ncbi.nlm.nih.gov/pubmed/33431899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20500-w
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