Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12

Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we show that mice develop inflamed lung tissue after being administered exosomes released from the lung epithelial cells exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp12 and Nsp13 (exo...

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Udgivet i:Mol Ther
Main Authors: Teng, Yun, Xu, Fangyi, Zhang, Xiangcheng, Mu, Jingyao, Sayed, Mohammed, Hu, Xin, Lei, Chao, Sriwastva, Mukesh, Kumar, Anil, Sundaram, Kumaran, Zhang, Lifeng, Park, Juw Won, Chen, Shao-yu, Zhang, Shuangqin, Yan, Jun, Merchant, Michael L., Zhang, Xiang, McClain, Craig J., Wolfe, Jennifer K., Adcock, Robert S., Chung, Donghoon, Palmer, Kenneth E., Zhang, Huang-Ge
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2021
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110335/
https://ncbi.nlm.nih.gov/pubmed/33984520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.05.005
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