Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m(6)A/p21 pathway

Evidence suggests that metformin might be a potential candidate for breast cancer treatment. Yet, its relevant molecular mechanisms remain to be fully investigated. We found that metformin could suppress the N6-methyladenosine (m(6)A) level in breast cancer cells significantly. The latter has an ess...

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Veröffentlicht in:Oncogenesis
Hauptverfasser: Cheng, Lin, Zhang, Xu, Huang, Yu-Zhou, Zhu, Yu-Lan, Xu, Ling-Yun, Li, Zhi, Dai, Xin-Yuan, Shi, Liang, Zhou, Xu-Jie, Wei, Ji-Fu, Ding, Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801402/
https://ncbi.nlm.nih.gov/pubmed/33431790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00290-y
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