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The PDZ Domain Protein SYNJ2BP Regulates GRK-Dependent Sst2A Phosphorylation and Downstream MAPK Signaling

The somatostatin receptor 2A (SST(2)) is a G-protein-coupled receptor (GPCR) that is expressed in neuroendocrine tissues within the gastrointestinal tract and brain, and is commonly overexpressed in many neuroendocrine tumors. Moreover, SST(2) agonists are used clinically as the primary pharmacologi...

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Publicat a:Endocrinology
Autors principals: Carr, Heather S, Chang, Jeffrey T, Frost, Jeffrey A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799432/
https://ncbi.nlm.nih.gov/pubmed/33313679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqaa229
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