Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids

Duplication or deficiency of the X‐linked MECP2 gene reliably produces profound neurodevelopmental impairment. MECP2 mutations are almost universally responsible for Rett syndrome (RTT), and particular mutations and cellular mosaicism of MECP2 may underlie the spectrum of RTT symptomatic severity. N...

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Pubblicato in:EMBO Mol Med
Autori principali: Trujillo, Cleber A, Adams, Jason W, Negraes, Priscilla D, Carromeu, Cassiano, Tejwani, Leon, Acab, Allan, Tsuda, Ben, Thomas, Charles A, Sodhi, Neha, Fichter, Katherine M, Romero, Sarah, Zanella, Fabian, Sejnowski, Terrence J, Ulrich, Henning, Muotri, Alysson R
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799367/
https://ncbi.nlm.nih.gov/pubmed/33501759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012523
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