SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity

There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo....

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Опубликовано в: :J Mol Cell Biol
Главные авторы: Petruk, Ganna, Puthia, Manoj, Petrlova, Jitka, Samsudin, Firdaus, Strömdahl, Ann-Charlotte, Cerps, Samuel, Uller, Lena, Kjellström, Sven, Bond, Peter J, Schmidtchen, and Artur
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799037/
https://ncbi.nlm.nih.gov/pubmed/33295606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjaa067
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