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Concentration- and pH-Dependent Oligomerization of the Thrombin-Derived C-Terminal Peptide TCP-25

Peptide oligomerization dynamics affects peptide structure, activity, and pharmacodynamic properties. The thrombin C-terminal peptide, TCP-25 (GKYGFYTHVFRLKKWIQKVIDQFGE), is currently in preclinical development for improved wound healing and infection prevention. It exhibits turbidity when formulate...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Petruk, Ganna, Petrlova, Jitka, Samsudin, Firdaus, Giudice, Rita Del, Bond, Peter J., Schmidtchen, Artur
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699335/
https://ncbi.nlm.nih.gov/pubmed/33228042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10111572
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