P-cresol and Indoxyl Sulfate Impair Osteogenic Differentiation by Triggering Mesenchymal Stem Cell Senescence

Chronic kidney disease (CKD) patients obtained high levels of uremic toxins progressively develop several complications including bone fractures. Protein-bound uremic toxins especially p-cresol and indoxyl sulfate are hardly eliminated due to their high molecular weight. Thus, the abnormality of bon...

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Detalhes bibliográficos
Publicado no:Int J Med Sci
Main Authors: Kamprom, Witchayapon, Tawonsawatruk, Tulyapruek, Mas-Oodi, Sumana, Anansilp, Korrarit, Rattanasompattikul, Manoch, Supokawej, Aungkura
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797544/
https://ncbi.nlm.nih.gov/pubmed/33437209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.48492
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