A Rare Potential Pathogenic Variant in the BDNF Gene is Found in a Brazilian Patient with Severe Childhood-Onset Obesity

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a pro-survival factor in the brain that also regulates energy balance. BDNF loss-of-function point mutations are responsible for haploinsufficiency, causing severe early-onset obesity. Up to date, only a few studies have sequenced this gene to...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes Metab Syndr Obes
Main Authors: da Fonseca, Ana Carolina Proença, Abreu, Gabriella de Medeiros, Palhinha, Lohanna, Zembrzuski, Verônica Marques, Campos Junior, Mario, Carneiro, João Regis Ivar, Nogueira Neto, José Firmino, Magno, Fernanda Cristina C Mattos, Rosado, Eliane Lopes, Maya-Monteiro, Clarissa Menezes, de Cabello, Giselda Maria Kalil, Cabello, Pedro Hernán, Bozza, Patricia Torres
Format: Artigo
Language:Inglês
Published: Dove 2021
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797284/
https://ncbi.nlm.nih.gov/pubmed/33442278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S267202
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items