Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease

BACKGROUND: Both serotonergic signalling disruption and systemic inflammation have been associated with the pathogenesis of Alzheimer’s disease (AD). The common denominator linking the two is the catabolism of the essential amino acid, tryptophan. Metabolism via tryptophan hydroxylase results in ser...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Whiley, Luke, Chappell, Katie E., D’Hondt, Ellie, Lewis, Matthew R., Jiménez, Beatriz, Snowden, Stuart G., Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Swann, Jonathan R., Hye, Abdul, Lovestone, Simon, Legido-Quigley, Cristina, Holmes, Elaine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797094/
https://ncbi.nlm.nih.gov/pubmed/33422142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00741-z
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