Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease

BACKGROUND: Both serotonergic signalling disruption and systemic inflammation have been associated with the pathogenesis of Alzheimer’s disease (AD). The common denominator linking the two is the catabolism of the essential amino acid, tryptophan. Metabolism via tryptophan hydroxylase results in ser...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Alzheimers Res Ther
Egile Nagusiak: Whiley, Luke, Chappell, Katie E., D’Hondt, Ellie, Lewis, Matthew R., Jiménez, Beatriz, Snowden, Stuart G., Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Swann, Jonathan R., Hye, Abdul, Lovestone, Simon, Legido-Quigley, Cristina, Holmes, Elaine
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2021
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797094/
https://ncbi.nlm.nih.gov/pubmed/33422142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00741-z
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