Validation of human microRNA target pathways enables evaluation of target prediction tools

MicroRNAs are regulators of gene expression. A wide-spread, yet not validated, assumption is that the targetome of miRNAs is non-randomly distributed across the transcriptome and that targets share functional pathways. We developed a computational and experimental strategy termed high-throughput miR...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Kern, Fabian, Krammes, Lena, Danz, Karin, Diener, Caroline, Kehl, Tim, Küchler, Oliver, Fehlmann, Tobias, Kahraman, Mustafa, Rheinheimer, Stefanie, Aparicio-Puerta, Ernesto, Wagner, Sylvia, Ludwig, Nicole, Backes, Christina, Lenhof, Hans-Peter, von Briesen, Hagen, Hart, Martin, Keller, Andreas, Meese, Eckart
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797041/
https://ncbi.nlm.nih.gov/pubmed/33305319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1161
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