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Structural basis of WLS/Evi-mediated Wnt transport and secretion
Wnts are evolutionarily conserved ligands that signal at short range to regulate morphogenesis, cell fate and stem cell renewal. The first and essential steps in Wnt secretion are their O-palmitoleation and subsequent loading onto the dedicated transporter WLS/Evi. We report the 3.2 Å resolution cry...
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| Publié dans: | Cell |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7797000/ https://ncbi.nlm.nih.gov/pubmed/33357447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.038 |
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