Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

While cell transplantation can rescue motor defects in Parkinson’s disease (PD) models, whether and how grafts functionally repair damaged neural circuitry in the adult brain is not known. We transplanted hESC-derived midbrain dopamine (mDA) or cortical glutamate neurons into the substantia nigra or...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Xiong, Man, Tao, Yezheng, Gao, Qinqin, Feng, Ban, Yan, Wei, Zhou, Yingying, Kotsonis, Thomas A., Yuan, Tingli, You, Zhiwen, Wu, Ziyan, Xi, Jiajie, Haberman, Alexander, Graham, Julia, Block, Jasper, Zhou, Wenhao, Chen, Yuejun, Zhang, Su-Chun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796915/
https://ncbi.nlm.nih.gov/pubmed/32966778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.08.014
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