Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms?

Alzheimer's disease (AD) is characterized by proteasome activity impairment, oxidative stress, and epigenetic changes, resulting in β-amyloid (Aβ) production/degradation imbalance. Apolipoprotein E (ApoE) is implicated in Aβ clearance, and particularly, the ApoE ε4 isoform predisposes to AD dev...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Principais autores: Piccarducci, Rebecca, Daniele, Simona, Polini, Beatrice, Carpi, Sara, Chico, Lucia, Fusi, Jonathan, Baldacci, Filippo, Siciliano, Gabriele, Bonuccelli, Ubaldo, Nieri, Paola, Martini, Claudia, Franzoni, Ferdinando
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796851/
https://ncbi.nlm.nih.gov/pubmed/33488947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8869849
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