Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3

Background/Aim: Fusion of histone-lysine N-methyltransferase 2A gene (KMT2A) with the Rho guanine nucleotide exchange factor 12 gene (ARHGEF12), both located in 11q23, was reported in some leukemic patients. We report a KMT2A-ARHGEF12 fusion occurring during treatment of a pediatric acute myeloid le...

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Detalhes bibliográficos
Publicado no:Cancer Genomics Proteomics
Main Authors: PANAGOPOULOS, IOANNIS, ANDERSEN, KRISTIN, EILERT-OLSEN, MARTINE, ZELLER, BERNWARD, MUNTHE-KAAS, MONICA CHENG, BUECHNER, JOCHEN, OSNES, LIV T.N., MICCI, FRANCESCA, HEIM, SVERRE
Formato: Artigo
Idioma:Inglês
Publicado em: International Institute of Anticancer Research 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796818/
https://ncbi.nlm.nih.gov/pubmed/33419897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21873/cgp.20242
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