Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity

Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason for treatment discontinuation. Mitochondrial dysfunction of complex I has been implicated in the pathophysiology of SAMS. The present study pro...

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Bibliografische gegevens
Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Avram, Vlad F., Chamkha, Imen, Åsander-Frostner, Eleonor, Ehinger, Johannes K., Timar, Romulus Z., Hansson, Magnus J., Muntean, Danina M., Elmér, Eskil
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796258/
https://ncbi.nlm.nih.gov/pubmed/33401621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010424
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