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Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose

Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western world. Extensive research has demonstrated that the...

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Bibliographic Details
Published in:PLoS One
Main Authors: Piel, Sarah, Chamkha, Imen, Dehlin, Adam Kozak, Ehinger, Johannes K., Sjövall, Fredrik, Elmér, Eskil, Hansson, Magnus J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135280/
https://ncbi.nlm.nih.gov/pubmed/32251487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231173
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