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Functional Comparison between VP64-dCas9-VP64 and dCas9-VP192 CRISPR Activators in Human Embryonic Kidney Cells

Reversal in the transcriptional status of desired genes has been exploited for multiple research, therapeutic, and biotechnological purposes. CRISPR/dCas9-based activators can activate transcriptionally silenced genes after being guided by gene-specific gRNA(s). Here, we performed a functional compa...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Javaid, Nasir, Pham, Thuong L. H., Choi, Sangdun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7795359/
https://ncbi.nlm.nih.gov/pubmed/33401508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010397
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