Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression

Fenofibrate slows the progression of clinical diabetic retinopathy (DR), but its mechanism of action in the retina remains unclear. Fenofibrate is a known agonist of peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor critical for regulating metabolism, inflammation and...

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Publicado en:J Clin Med
Main Authors: Enright, Jennifer M., Zhang, Sheng, Thebeau, Christina, Siebert, Emily, Jin, Alexander, Gadiraju, Veda, Zhang, Xiaodong, Chen, Shiming, Semenkovich, Clay F., Rajagopal, Rithwick
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794763/
https://ncbi.nlm.nih.gov/pubmed/33396512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm10010126
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