Tonabersat Inhibits Connexin43 Hemichannel Opening and Inflammasome Activation in an In Vitro Retinal Epithelial Cell Model of Diabetic Retinopathy

This study was undertaken to evaluate the connexin hemichannel blocker tonabersat for the inhibition of inflammasome activation and use as a potential treatment for diabetic retinopathy. Human retinal pigment epithelial cells (ARPE-19) were stimulated with hyperglycemia and the inflammatory cytokine...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Lyon, Heather, Shome, Avik, Rupenthal, Ilva D., Green, Colin R., Mugisho, Odunayo O.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794685/
https://ncbi.nlm.nih.gov/pubmed/33396676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010298
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