GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice

The G protein-coupled receptor 109 A (GPR109A) is robustly expressed in osteoclastic precursor macrophages. Previous studies suggested that GPR109A mediates effects of diet-derived phenolic acids such as hippuric acid (HA) and 3-(3-hydroxyphenyl) propionic acid (3-3-PPA) on promoting bone formation....

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Veröffentlicht in:Commun Biol
Hauptverfasser: Chen, Jin-Ran, Zhao, Haijun, Wankhade, Umesh D., Chintapalli, Sree V., Li, Can, Gai, Dongzheng, Shankar, Kartik, Zhan, Fenghuang, Lazarenko, Oxana P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794563/
https://ncbi.nlm.nih.gov/pubmed/33420329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01564-2
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