Preclinical safety and immunogenicity of Streptococcus pyogenes (Strep A) peptide vaccines

We have developed two candidate vaccines to protect against multiple strains of Strep A infections. The candidates are combinatorial synthetic peptide vaccines composed of a M protein epitope (J8 or p*17) and a non-M protein epitope (K4S2). To enhance immunogenicity, each peptide is conjugated to th...

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Vydáno v:Sci Rep
Hlavní autoři: Reynolds, Simone, Pandey, Manisha, Dooley, Jessica, Calcutt, Ainslie, Batzloff, Michael, Ozberk, Victoria, Mills, Jamie-Lee, Good, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794325/
https://ncbi.nlm.nih.gov/pubmed/33420258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80508-6
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