M-protein based vaccine induces immunogenicity and protection from Streptococcus pyogenes when delivered on a high-density microarray patch (HD-MAP)

We evaluated vaccination against Streptococcus pyogenes with the candidate vaccine, J8-DT, delivered by a high-density microarray patch (HD-MAP). We showed that vaccination with J8-DT eluted from a coated HD-MAP (J8-DT/HD-MAP), induced similar total IgG responses to that generated by vaccination wit...

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Veröffentlicht in:NPJ Vaccines
Hauptverfasser: Mills, Jamie-Lee S., Jayashi Flores, Cesar M., Reynolds, Simone, Wun, Christine, Calcutt, Ainslie, Baker, S. Ben, Murugappan, Senthil, Depelsenaire, Alexandra C. I., Dooley, Jessica, Fahey, Paul V., Forster, Angus H., Pandey, Manisha, Good, Michael F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414110/
https://ncbi.nlm.nih.gov/pubmed/32802413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-020-00222-2
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