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Panton-Valentine Leucocidin of Staphylococcus aureus Induces Oxidative Stress and Neurotransmitter Imbalance in a Retinal Explant Model

PURPOSE: Endophthalmitis models have reported the virulent role of Panton-Valentine leucocidin (PVL) secreted by Staphylococcus aureus on the retina. PVL targets retinal ganglion cells (RGCs), expressing PVL membrane receptor C5aR. Interactions between PVL and retinal cells lead to glial activation,...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Wurtz, Mathieu, Ruhland, Elisa, Liu, XuanLi, Namer, Izzie-Jacques, Mazzoleni, Viola, Lipsker, Dan, Keller, Daniel, Prévost, Gilles, Gaucher, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794257/
https://ncbi.nlm.nih.gov/pubmed/33393970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.1.4
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