Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

Coronaviruses spike (S) glycoproteins mediate viral entry into host cells by binding to host receptors. However, how the S1 subunit undergoes conformational changes for receptor recognition has not been elucidated in Alphacoronavirus. Here, we report the cryo-EM structures of the HCoV-229E S trimer...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Song, Xiyong, Shi, Yuejun, Ding, Wei, Niu, Tongxin, Sun, Limeng, Tan, Yubei, Chen, Yong, Shi, Jiale, Xiong, Qiqi, Huang, Xiaojun, Xiao, Shaobo, Zhu, Yanping, Cheng, Chongyun, Fu, Zhen F., Liu, Zhi-Jie, Peng, Guiqing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794242/
https://ncbi.nlm.nih.gov/pubmed/33420048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20401-y
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