Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

Coronaviruses spike (S) glycoproteins mediate viral entry into host cells by binding to host receptors. However, how the S1 subunit undergoes conformational changes for receptor recognition has not been elucidated in Alphacoronavirus. Here, we report the cryo-EM structures of the HCoV-229E S trimer...

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Udgivet i:Nat Commun
Main Authors: Song, Xiyong, Shi, Yuejun, Ding, Wei, Niu, Tongxin, Sun, Limeng, Tan, Yubei, Chen, Yong, Shi, Jiale, Xiong, Qiqi, Huang, Xiaojun, Xiao, Shaobo, Zhu, Yanping, Cheng, Chongyun, Fu, Zhen F., Liu, Zhi-Jie, Peng, Guiqing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794242/
https://ncbi.nlm.nih.gov/pubmed/33420048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20401-y
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