hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways

Background: Human bone marrow-derived mesenchymal stromal cells (hBMSCs) provide a promising therapeutic approach in the cell-based therapy of osteoarthritis (OA). However, several disadvantages evolved recently, including immune responses of the host and regulatory hurdles, making it necessary to s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Bioeng Biotechnol
Hauptverfasser: Li, Shushan, Stöckl, Sabine, Lukas, Christoph, Götz, Julia, Herrmann, Marietta, Federlin, Marianne, Grässel, Susanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Bioengineering and Biotechnology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793861/
https://ncbi.nlm.nih.gov/pubmed/33425869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.603598
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