A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis

Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset of deaths. In Vietnam, the survival benefit of anti-inflammatory corticos...

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Publicado en:eLife
Autores principales: Whitworth, Laura, Coxon, Jacob, van Laarhoven, Arjan, Thuong, Nguyen Thuy Thuong, Dian, Sofiati, Alisjahbana, Bachti, Ganiem, Ahmad Rizal, van Crevel, Reinout, Thwaites, Guy E, Troll, Mark, Edelstein, Paul H, Sewell, Roger, Ramakrishnan, Lalita
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793626/
https://ncbi.nlm.nih.gov/pubmed/33416499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61722
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